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Cytoskeleton

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The structural scaffolding governing how chondrocytes sense and respond to mechanical and inflammatory cues.

The word cytoskeletal appears in the title of Jessica's master's thesis. IL-1β-Mediated Cytoskeletal Remodelling and Transcriptional Reprogramming in Chondrocytes began in March 2026 at G.E.R.N., and the remodelling in that title is what she measures. Her method is morphological before it is molecular. Working from immunofluorescence-stained chondrocytes read through high-content single-cell image analysis, she treats the shape and internal organisation of each individual cell as the readout rather than averaging a population and losing the variation inside it. This is the single-cell morpho-proteomic profiling named in her research summary, and it is a G.E.R.N. speciality she trained into rather than arrived with. The numbers come out into Excel, VBA, R and SigmaPlot. She helped build parts of the assay and the protocol that generate them, and has since taught the same workflow to incoming laboratory interns. What the science page describes as a pathway is, at her bench, a change in how a cell looks.

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